Endocrine Abstracts

Aim of the work: The effects of subclinical hyperthyroidism (SCH) on bone and heart have been well documented. Effects on other parameters like lipids metabolism and weight regulation have also been reported but mainly in cross-sectional studies. The potential benefits of treatment of endogenous subclinical hyperthyroidism are more controversial as few large controlled studies on clinical outcomes have been performed. ATA guidelines recommend treatment according to the severit...

The pathogenesis of pheochromocytomas (pheo) is poorly understood and malignant pheo need new treatment options. mTOR inhibitors, as sirolimus (S) and everolimus (E), are new promising antineoplastic drugs.Aim: To evaluate whether the IGF/mTOR pathways have a role in the pathogenesis and whether S and E may have antiproliferative effects in pheo.In 24 human pheo and two normal adrenal medulla (NM), we evaluated the mRNA expression ...

Background: Military personnel on operational deployment commonly lose weight despite the adequate supply of rations. Moderate weight loss (~5% body mass) occurred during the initial phase of a 6-month deployment to Afghanistan without affecting physical fitness. Reasons for this weight loss are presently unknown. We sought to establish whether changes in appetite regulatory hormones contribute to the observed weight loss.Methods: Body mass and body comp...

Introduction: The clinical relevance of low IGF-I levels, caused by cranial radiotherapy, in adult childhood cancer survivors has not been studied extensively. We evaluated whether IGF-I is a useful marker for altered body composition and growth hormone deficiency in this group.Methods: We analyzed retrospective data from 610 adult childhood cancer survivors, retrieved from the late effects clinic. Median age at diagnosis was 6 years (interquartile range...

Aim: In this study, our aim was to investigate frequency of impaired glucose tolerance (IGT), undiagnosed diabetes mellitus (DM) and presence of insulin resistance by HOMA.Material and method: Fifty-five primary hyperparathyroid patients without known glucose tolerance were included in this study. The control group was with similar BMI, normocalcemic, without known glucose tolerance. Seventy-five gram oral glucose tolerans test was performed to PHP patie...

Background: Patients with classical congenital adrenal hyperplasia (CAH) require life-long therapy with glucocorticoids in order to suppress the androgen production through the inhibition of CRH and consequently ACTH. The therapy must be balanced to avoid either iatrogen hypercortisolism or hyperandrogenism both potentially associated with adverse cardiovascular risk profile.Objective: Aim of this cross-sectional controlled study was to investigate the m...

Introduction: The isoform A of the human insulin receptor (IR-A) binds insulin with high affinity, and binds IGF-II with a 3–10 folds lower affinity. Cells lacking the insulin-like Growth Factor-I receptor (IGF-IR) and overexpressing the human IR-A (R-/IR-A cells) respond to IGF-II with reduced metabolic effects but unaltered or increased mitogenesis as compared to insulin stimulation. We hypothesized that this altered ratio of metabolic-to-mitogenic effects of IGF-II in ...

Aim: The relationship between hyperprolactinoma and insulin resistance has been shown in many studies. It is also known that hyperprolactinoma causes changes in carbohydrate and lipid metabolism. The aim of our study is to evaluate insulin resistance in patients with prolactinoma and see the effect of treatment on insulin resistance and karotis intima media thickness (CIMT).Material and methods: Twenty-two female patients diagnosed biochemically and radi...

Aim: Antineutrophil cytoplasmic antibody (ANCA) positivity is usually determined in medium and large vessel vasculitis. This antibody has two different forms. Cytoplasmic ANCA (PR3-ANCA) occurs against proteinase-3, while perinuclear ANCA (MPO-ANCA) occurs against myeloperoxidase and bactericidal- permeability increasing proteins. The presence of ANCA is mostly seen in systemic vasculitis and also in drug induced vasculitis. There is no sufficient data about prevalence of posi...

Aminobisphosphonates impair osteoclast cell function and reduce bone remodelling rate. It has been speculated that atypical femoral fractures in patients on bisphosphonates are the result of impaired bone remodelling.The primary aim of this prospective study was to assess levels of bone remodelling in patients with osteoporosis on aminobisphosphonate therapy by measurement of bone turnover markers. The secondary aim was to assess the adequacy of concomit...